Die Spezifizitat Serologischen Reaktionen
Berlin: Julius Springer 1933. First Edition. [4], 123, [1] pages. 8vo. Tan cloth binding with black printed titles. A presentation copy INSCRIBED by the author on the front flyleaf "To Dr. Goebel Sincerely, K. Landsteiner". Ex-library Goebel Collection (Rockefeller University), properly de-accessioned. Indications of removed library label on spine. Bookplate and small removed label on front pastedown endpaper. Shelf wear to the corners and head/tail spine, one page with a few pencil underlines. Overall a very good copy. Price temporarily reduced by Consignor. Very Good. Cloth. [20168]
Walther Frederick Goebel (12/24/1899-11/1/1993) was an American immunologist and an organic chemist, a National Academy of Sciences member and long time Rockefeller University professor. Karl Landsteiner was a colleague of Goebel's at Rockefeller and was awarded the 1930 Nobel Prize in Medicine for 'his discovery of human blood groups'. Specifically, he explained the immunological nature of blood typing (i.e. someone with an A blood type could receive blood from an A donor because the A donor's blood carries a non-foreign antigen while an A recipient could not receive from a B donor because the B donor's blood has a foreign antigen that would be attacked by the A recipient's immune system) and linked these blood groups to Mendelian genetics.
This book, Die Spezifizitat Serologischen Reaktionen, ('The Specificity of Serological Reactions') outlines the methodology that Landsteiner used in his Nobel studies (and beyond). This monograph describes the immunological studies that were used to study cross-reactions between different individuals (as in the ABO blood example) and different species. In the case of the latter, these early techniques involved injecting serum (including antigens) from, for example, a pig, into, for example, a goat and allowing the goat to develop antibodies against the pig's antigens. The goat's antibodies would be isolated and used to study immune responses. For instance, the isolated goat antibodies should form a precipitate in the presence of pig serum (precipitate indicating antibody-antigen binding) while no reaction would be seen when the isolated goat antibodies were in the presence of, say, rabbit serum.
Scarce signed. Garrison/Morton 5/2576.2
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