Philadelphia: Printed for and Sold by James Humphreys ; Hopkins & Earle ; Kimber & Conrad ; B. & T. Kite ; and Thomas Dobson ; Also, White, Burditt & Co. Boston 1809. Second American Edition. xii, 427, [2-publisher's book checklist], [2-ad for "Struggles Through Life" by Harriott - "Now in press"] pages. 7 x 4 1/8 inches. A rough copy. Worn leather, front joint starting at top. Red spine label "CHYMISTRY". Page 419 misnumbered 418. Page 388 notes "End of the London copy" followed by APPENDIX. Plates foxed. Plate 6 torn with old thread stitched make-do repair. Plate XII too closely trimmed with minor loss to illustration (facsimile included). Leather worn, corners soft with some worm boles at spine and turned corners. Front blank flyleaf lacking, tear repair to title page. Probably ex-library or ex-libris copy with old removal markings (old glue residues - two places front pastedown, one rear w/blue paper residue, probably label removed from spine). Both hinges with cords showing but still readable. Several pieces of paper loss lower margin first few pages (no text loss). Inked notation at base of page 176 correcting typo in the text. Last leaf proud of the textblock. Withall, a fair copy. Fair. Boards. 
"Born in London of Swiss parents, Jane Marcet (nee Haldimand, 1769-1858) married Alexander John Gaspard Marcet in 1799. Although published anonymously, this work was quickly recognized to be by Mrs. Marcet. It is written in an easy dialogue style, in which Marcet ("Mrs. B") instructs two young ladies ... in the principles and discoveries of modern chemistry...Evidently printed in very small number, the first edition is rare. Most copies were handled by young people and were literally read to pieces." (Neville, referencing the 1806 London edition)."
Michael Faraday as a young man working in a bindery happened upon Marcet's work and credited it with establishing his first foundations in chemistry. "So when I questioned Mrs. Marcet's book by such little experiments as I could find to perform, and found it true to the facts as I could understand them, I felt that I had got hold of an ancor in chemical knowledge and clung fast to it. Hence my deep veneration for Mrs. Marcet..." (Smith, Old Chemistries, pp. 68-69. quoting from a Faraday letter to de la Rive") Given the blowpipe addition here, Smith also surmises that Joseph Cloud might have been the editor of this edition.
This edition is copyrighted Dec. 13, 1808. The earliest advertisement we've seen is Bookseller J.P. and J.W. Skelton who exclaim in their June 21, 1809 Pittsburgh Weekly Gazette advertisement that they just received from Philadelphia "Conversations on Chymistry." "Struggles through Life" by author Harriott is advertised in rear as "Now in Press" and we know was reviewed as early as January 1808. Both lean towards an early 1809 Humphreys publication date. We only note this because there exists a work also dated 1809, with New Haven imprint and a similar title ("Chemistry" rather than "Chymistry") and includes some additional work by Davy. This New Haven work is far more common in our experience, and contains a May 1809 dated catalog in rear. Given this we lean towards the Philadelphia edition (as here) preceding the New Haven work.
Rink, E. (A Checklist of Technical Americana), 665. Smith, Old Chemistries. Not in Cole, Bolton, Duveen, or the Neville Collection.